Senior Research Scientist – Neuroscience

Required Qualifications

• Deep hands-on experience (3+ years) developing and executing cellular or tissue-based assays for small-molecule target engagement, degradation, or specificity assessment.
• Demonstrated expertise with plate-based assay development, including assay design, optimization, troubleshooting, validation, control selection, reproducibility assessment, and artifact identification.
• Experience using probe-based or proximity-based strategies, such as biotinylated probes, photoaffinity labeling, NanoBRET, TR-FRET, AlphaLISA, luciferase-based assays, or related approaches.
• Experience adapting assays for robustness, scalability, miniaturization, and multi-well plate formats to support compound profiling or screening workflows.
• Strong data analysis skills using tools such as Prism, Gene Data, Python, or R.
• Track record of scientific contributions (publications, patents, or program impact) and cross-functional collaboration skills.
• Background in neurodegenerative disease biology (e.g., tau, alpha-synuclein, TDP-43, amyloid-beta) strongly desired.
• Experience working with rodent and human-derived tissues (e.g., post-mortem brain) a plus.
• Familiarity with biophysical binding assays (SPR, MST, FP) and orthogonal validation strategies a plus.
• Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship.
• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.